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ORIENTIN Basic information
ORIENTIN Chemical Properties
  • Melting point:260-285°C
  • Boiling point:816.1±65.0 °C(Predicted)
  • Density 1.759±0.06 g/cm3(Predicted)
  • storage temp. Keep in dark place,Sealed in dry,2-8°C
  • solubility 1 M NaOH: soluble1mg/mL, clear, yellow-orange
  • pka6.24±0.40(Predicted)
  • form powder
  • color yellow
Safety Information
  • Safety Statements 24/25
  • WGK Germany 3
  • RTECS DJ3009300
  • HS Code 29389090
ORIENTIN Usage And Synthesis
  • DescriptionOrientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; Item No. 14805) radicals with an IC50 value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC50 value of 11.7 μg/ml and a cytotoxic concentration (CC50) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.
  • Chemical PropertiesYellow powder
  • UsesOrientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects.
  • DefinitionChEBI: A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.
ORIENTIN(28608-75-5)Related Product Information
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