Benzo[j]fluoranthene is a polycyclic aromatic hydrocarbon that has tumour initiating activity and can be found in soot, oil, water and soil extracts as a common pollutant.
ChEBI: Benzo[j]fluoranthene is a member of naphthalenes.
Yellow crystals. Insoluble in water.
Dust/air mixture may ignite and explode. Insoluble in water.
Vigorous reactions, sometimes amounting to explosions, can result from the contact between aromatic hydrocarbons, such as BENZO(J)FLUORANTHENE, and strong oxidizing agents. They can react exothermically with bases and with diazo compounds. Substitution at the benzene nucleus occurs by halogenation (acid catalyst), nitration, sulfonation, and the Friedel-Crafts reaction.
Benzo[j]fluoranthene is a cancer suspectagent. Animal studies present sufficient evidence on its carcinogenicity. It may causetumor in lungs and skin.
Benzo[j]fluoranthene was tested
for carcinogenicity by dermal application in mice in four
studies, by intraperitoneal injection into
newborn mice in two studies and by intrapulmonary
implantation into rats in one study. With the
exception of one study on newborn female mice, benzo[j]
fluoranthene exhibited a significant carcinogenic activity in
all of the assays.
The initial risk screening level and secondary risk screening level (SRSL) for benzo(a)pyrene
(B(a)P) are 6E-4 μg/m3 and 6E-3 μg/m3, respectively. The IRSL and SRSL were derived from
the inhalation unit risk (IUR) factor for B(a)P of 1.76E-3 per μg/m3 (1.1E-3 per μg/m3 multiplied
by an age-dependent adjustment factor or ADAF of 1.6).
