MOUSE ANTI HUMAN VIMENTIN 抗体

Mouse Anti Human Vimentin Antibody Mouse Vimentin antibody will recognize most mammalian Vimentin except mouse and rat. Unconjugated EL, WB, IP, IH

Vimentin antibody AbD2701

Western blot analysis of whole cell lysates probed with vimentin antibody (MA00008) followed by detection with HRP conjugated Goat anti Human IgG F(ab)2 (1/2500, STAR126P) and visualized on the ChemiDoc MP with 2 second exposure. Arrow points to vimentin (molecular weight 54 kDa).

Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines.

MOUSE ANTI HUMAN VIMENTIN抗体是以HUMAN VIMENTIN为抗原以小鼠为宿主制得的免疫抗体，可以特异性结合HUMAN VIMENTIN。主要用于检测HUMAN VIMENTIN的Western Blot、IHC-P、IF、ELISA、Co-IP等多种免疫学实验。