2-(2,4-Difluorophenyl)pyridine

109-04-6

144025-03-6

391604-55-0

General procedure for the synthesis of 2-(2,4-difluorophenyl)pyridine from 2-bromopyridine and 2,4-difluorophenylboronic acid: 2-bromopyridine (2.01 mL, 21.1 mmol), 2,4-difluorophenylboronic acid (4.00 g, 25.3 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.732 g, 0.633 mmol) were added to a reflux condenser equipped with a round bottom flask and dissolved in 50 mL of tetrahydrofuran (THF). Subsequently, 30 mL of 2 M sodium carbonate (Na2CO3) aqueous solution was added to the reaction system. The reaction mixture was heated to reflux at 70°C for 24 hours. After completion of the reaction, it was cooled to room temperature and the crude reaction mixture was poured into water and extracted with dichloromethane (CH2Cl2, 50 mL x 3). The organic phases were combined and dried with anhydrous magnesium sulfate. Purification by silica gel column chromatography (eluent: n-hexane/ethyl acetate=4:1, v/v) afforded the target product 2-(2,4-difluorophenyl)pyridine (dfppy 1) as a colorless liquid (3.90 g, 97% yield).