化合物 T16773
化合物 T16773 用途与合成方法
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Amyloid β42
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ATM
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Protein phosphatase 5
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Apoptosis
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Ro 90-7501 significantly enhances radiosensitivity compared with control HeLa and ME-180 cells. Ro 90-7501 significantly increases apoptosis and impaired cell cycle after irradiation. Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation.
RO 90-7501, itself affects neither IFN-β nor NFκB promoter activity, but significantly enhances poly I:C-induced IFN-β promoter activation and inhibits the activation of NFκB in a dose-dependent manner. Treatment of cells with RO 90-7501 significantly enhances the antiviral activity of poly I:C.
Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume.
| Animal Model: | Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation |
| Dosage: | 5 μg/g |
| Administration: | Intraperitoneal injection; daily; for 21 days |
| Result: | Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group. |
