Dnp-PLAYWAR (trifluoroacetate salt)

Dnp-PLAYWAR is a fluorogenic substrate for matrix metalloproteinase-8 (MMP-8) and MMP-26.1,2 The activity of MMP-8 and MMP-26 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.WARNING This product is not for human or veterinary use.

[1] SARAH NETZEL-ARNETT . Continuously recording fluorescent assays optimized for five human matrix metalloproteinases[J]. Analytical biochemistry, 1991, 195 1: Pages 86-92. DOI: 10.1016/0003-2697(91)90299-9
[2] H. PARK. Peptide Substrate Specificities and Protein Cleavage Sites of Human Endometase/Matrilysin-2/Matrix Metalloproteinase-26*[J]. The Journal of Biological Chemistry, 2002, 315 1: 35168-35175. DOI: 10.1074/jbc.m205071200