Mca-P-Cha-G-Nva-HA-Dap(Dnp)-NH2 (trifluoroacetate salt)

Mca-P-Cha-G-Nva-HA-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26.1,2 Upon cleavage by MMP-1, MMP-3, or MMP-26, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.WARNING This product is not for human or veterinary use.

[1] H. PARK. Peptide Substrate Specificities and Protein Cleavage Sites of Human Endometase/Matrilysin-2/Matrix Metalloproteinase-26*[J]. The Journal of Biological Chemistry, 2002, 315 1: 35168-35175. DOI: 10.1074/jbc.m205071200
[2] V. KNÄUPER. The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity.[J]. European journal of biochemistry, 2001, 1 1: 1888-1896. DOI: 10.1046/j.1432-1327.2001.02062.x