2,6-Dichlorophenyl isothiocyanate may be used as a precursor to synthesize 1-(2-aminoethyl)-2-cyano-3-(2,6-dichlorophenyl)guanidine.
2,6-Dichlorophenyl isothiocyanate is an isothiocyanate derivative. It has been synthesized by using 2,6-dichlorobenzaldehyde oxime as a starting reagent.
2.00 mmol 2,6-dichlorophenyl dithiocarbamic acid triethylammonium salt was added to a 50 mL aubergine flask, 8.00 mL of acetonitrile, 4.0 mmol of triethylamine were added sequentially, and then stirred at 0C. During stirring, 1.00 mmol of bis-tribromo 1,3-dipyridinium salts propane was added in batches, and then the reaction was held at 0C for 30 min after addition, and then raised to room temperature for stirring, and the reaction was carried out by TLC (thin layer chromatography). During the reaction, the reaction was detected by TLC (thin layer chromatography, unfolding agent: petroleum ether), and the reaction was found to be complete by TLC at 16 h. The reaction was then extracted and filtered, and the obtained filter cake was recycled (for the recycling method, see Example of recycling of bis-tribromo-1,3-dipyridinium salts of propane), and the obtained filtrate was concentrated, and the concentrated filtrate was subjected to column chromatography, and a yellow solid was obtained as 2,6-dichloroisothiocyanato phenyl ester (0.129 g, 29.5%), m.p. = 40-41 C.
