(8-chloronaphthalen-1-yl)-(1-pentylindol-3-yl)methanone

JWH 398 is a synthetic cannabinoid (CB) that acts as an agonist at both the central CB₁ receptor and the peripheral CB₂ receptor (K_is = 2.3 and 2.8 nM, respectively).¹ It has been detected as an additive of herbal mixtures.² JWH 398 8-chloronaphthyl isomer differs structurally from JWH 398 by having chlorine positioned on the naphthyl rings at the 8, rather than the 4, position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

1. Huffman, J.W. Cannabimimetic indoles, pyrroles, and indenes: Structure-activity relationships and receptor interactions The cannabinoid receptors ,49-95(2009).
2. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan Leg. Med. (Tokyo) 13(3),109-115(2011).