Milbemycin A4 is the prominent member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin 4 is used as a nematocide and insecticide.
Milbemycin A4 is a macrolide compound that is a member of a complex family of macrocyclic lactones that contain structural group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. Antibacterial and insecticide (1,2). It potentiates glutamate and GABA-gated chloride-channel opening. Used in the synthesis of Milbemycin A17 (3).
Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A4 is the dominant member of a group of analogues containing a 25-ethyl substituent. Milbemycin A4 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act on chloride-gated ion channels.
ChEBI: Milbemycin A4 is a milbemycin.
