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FMOC-ARG(ME,PBF)-OH

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FMOC-ARG(ME,PBF)-OH Basic information
FMOC-ARG(ME,PBF)-OH Chemical Properties
  • Density 1.33
  • storage temp. Store at -15°C to -25°C.
  • pka3.80±0.21(Predicted)
FMOC-ARG(ME,PBF)-OH Usage And Synthesis
  • DescriptionFMOC-Arg (ME, PBF)-OH is a kind of protected form of arginine. Arginine is double-protected by butyloxycarbonyl (BOC) and 2, 2, 4, 6, 7-pentamethyldihydrobenzofuran-5-sulfonyl (PBF). It is a derivative for introducing mono-methyl-arginine during Fmoc SPPS. Coupling can be carried out using any standard activation method. PBF protecting group can be removed by TFA-mediated cleavage reaction. As a kind of protected amino acid, it is an important intermediate in various fields such as peptide synthesis, asymmetric synthesis, medicinal chemistry as well as polymer chemistry.
  • Chemical PropertiesWhite powder
  • UsesFmoc-?Arg(Me,?pbf)?-?OH can be used as reactant/reagent in design, synthesis and structure-activity relationship of macrocyclic peptidomimetics that bind to WDR5 and block WDR5-MLL protein-protein interaction.
  • Referenceshttps://www.merckmillipore.com/CN/zh/product/Fmoc-Arg%28Me%2CPbf%29-OH,MDA_CHEM-852105?ReferrerURL=https%3A%2F%2Fguge6.firstguo.com%2F&bd=1
    https://en.wikipedia.org/wiki/Peptide_synthesis
    Kim, Tae-il, et al. "Arginine-conjugated polypropylenimine dendrimer as a non-toxic and efficient gene delivery carrier." Biomaterials 28.11 (2007): 2061-2067.
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