(ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR770 (667-676)

SEVNLDAEFR is a substrate for BACE1[1].

Substrate for assaying β-secretase activity that corresponds to the "Swedish" Lys-Met/Asn-Leu mutation of the amyloid precursor protein β-secretase cleavage site.

[1] Machálková M, et al. A label-free MALDI TOF MS-based method for studying the kinetics and inhibitor screening of the Alzheimer's disease drug target β-secretase. Anal Bioanal Chem. 2018 Nov;410(28):7441-7448. DOI:10.1007/s00216-018-1354-6