CIS-ENTACAPONE

cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone . It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.

Orange Solid

cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian.

ChEBI: 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a hydroxycinnamic acid.

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[3] NADEJDA SOUKHOVA. Development of characterization methods for entacapone in a pharmaceutical bulk[J]. Journal of pharmaceutical and biomedical analysis, 2011, 54 4: Pages 860-865. DOI: 10.1016/j.jpba.2010.10.019