TB5 性质
| 熔点 | 132-134 °C |
|---|---|
| 沸点 | 468.5±45.0 °C(Predicted) |
| 密度 | 1.440±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：33mg/mL； DMSO：33mg/mL；乙醇：1mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 4.30±0.24(Predicted) |
| 颜色 | 白色至黄色 |
| InChI | 1S/C15H14BrNOS/c1-17(2)12-6-3-11(4-7-12)5-8-13(18)14-9-10-15(16)19-14/h3-10H,1-2H3/b8-5+ |
| InChIKey | PTLDLBSWTKNYCY-VMPITWQZSA-N |
| SMILES | CN(C)C(C=C1)=CC=C1/C=C/C(C2=CC=C(Br)S2)=O |
TB5 用途与合成方法
| Target | Value |
|
MAO-B
() | 110 nM(Ki) |
TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with K i and SI values of 0.11±0.01μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively.
Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8.
TB5 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-100975 | 948841-07-4 | 5 mg | 500 | |
| 2026-09-15 | HY-100975 | 948841-07-4 | 948841-07-4 | 10mM * 1mLin DMSO | 550 |
