基本属性 生物活性靶点体外研究体内研究 用途与合成方法 TB5 价格(试剂级) 供应商
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TB5

TB5

中文名称:TB5
英文名称:TB5
CAS号:948841-07-4
分子式:C15H14BrNOS
分子量:336.25
EINECS号:
Mol文件:948841-07-4.mol
TB5 结构式

TB5 性质

沸点 468.5±45.0 °C(Predicted)
密度 1.440±0.06 g/cm3(Predicted)
储存条件 Store at -20°C
溶解度 DMF:33mg/mL; DMSO:33mg/mL;乙醇:1mg/mL
形态 结晶固体
酸度系数(pKa) 4.30±0.24(Predicted)

TB5 用途与合成方法

TB5是一种有效的、选择性MAO-B抑制剂,对MAO-B和MAO-A的Ki值分别为110 nM和1450 nM。
TargetValue
MAO-B
()
110 nM(Ki)

TB5 and TB8 interacts with the catalytic site of hMAO-B and hMAO-A with a competitive mode of inhibition. TB5 shows the best inhibitory activity and higher selectivity toward hMAO-B, with K i and SI values of 0.11±0.01μM and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A inhibition by compound TB8 are completely reversed after 24 h of dialysis. Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM, resulting in cell viabilities of 95.75% and 84.59 %, respectively.

Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8.

TB5 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-100975 5 mg 500
2024-01-25 HY-100975 948841-07-4 948841-07-4 10mM * 1mLin DMSO 550

TB5供应商 更多

上海瀚香生物科技有限公司
现货
联系电话:17754423994 17754423994
产品介绍:
英文名称:TB5
CAS:948841-07-4
纯度:98% COA NMR HPLC
包装信息:1g;10g;100g
备注:标准品
库存量:5g
现货日期:2024/3/18 17:04:16
上海楼岚生物科技有限公司
联系电话:021-52996696,15000506266 15000506266
产品介绍:
英文名称:TB5
CAS:948841-07-4
纯度:98% HPLC
包装信息:5mg,10mg,50mg,100mg,1g,5g
上海泽涵 生物医药科技有限公司
联系电话:021-61350663 13052117465
产品介绍:
英文名称:TB5
CAS:948841-07-4
纯度:98%
包装信息:1g;10g
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:TB5
CAS:948841-07-4
纯度:99%
包装信息:1mg;5mg;10mg
备注:试剂级
上海超岚化工科技中心
联系电话:QQ:65489617 15618227136
产品介绍:
英文名称:TB5
CAS:948841-07-4
纯度:98%
包装信息:5MG;10MG;50MG;100MG,1G,5G,100G
备注:仅供科研