Biotin-PEG4-hydrazide is a biotinylation reagent that can be used to label glycoproteins, carbohydrate-containing compounds that have oxidizable sugars or aldehydes. Hydrazine moiety reacts with an aldehyde to form semi-permanent hydrazone bonds. The hydrophilic PEG arm imparts water solubility that is transferred to the biotinylated molecule.
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
reagent type: cross-linking reagent
reaction type: Biotinylations
reactivity: carbonyl reactive
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:
10.1038/nchembio.2329
