Trabodenoson (6.0%), demonstrating an average IOP drop of 2.45 ± 0.38 mm Hg in young mice over 7 days (downregulation)[1].
Topical trabodenoson significantly upregulates nestin expression in the ONH of induced eyes compared with vehicle-treated no-induced eyes[2].
Trabodenoson-treated eyes have significantly reduced optic nerve (ON) edema compared with vehicle-treated eyes. RGC counts are higher in Trabodenoson-treated eyes compared to vehicle (74% versus 47% of the contralateral eye)[2].
| Animal Model: | Young (3-4 months old) and aged (12 months old)[1]. |
| Dosage: | 3% or 6% in 10 μL. |
| Administration: | Eye drop for 7 consecutive days. |
| Result: | Decreased IOP. |
| Animal Model: | Rats[2]. |
| Dosage: | 3%. |
| Administration: | Topical delivery daily. |
| Result: | Had significantly reduced optic nerve (ON) edema. |
