A-1210477
A-1210477 性质
| 沸点 | 1027.4±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.32±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 不溶于DMSO；不溶于水；不溶于乙醇 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 4.43±0.30(Predicted) |
| 颜色 | 白色至米白色 |
| InChIKey | MRLDHNSBXWSDDL-UHFFFAOYSA-N |
| SMILES | O=C(O)C(N1CCN2CCOCC2)=C(C3=C1C(C4=C(N(N=C4C)C)COC5=CC=C(C=C5)N6CCN(CC6)S(=O)(N(C)C)=O)=CC=C3)CCCOC7=C8C=CC=CC8=CC=C7.[H]Cl |
A-1210477 用途与合成方法
|
Mcl-1 0.45 nM (Ki) |
Bcl-2 132 nM (Ki) |
Bfl-1 660 nM (Ki) |
Bcl-W 2280 nM (Ki) |
Apoptosis
|
A-1210477 (10 μM) reduces the amount of BIM co-immunoprecipitated with MCL-1 antibody, and triggers MCL-1 elevation in a variety of cancer cell lines, including the breast cancer cell line HCC-1806. A-1210477 inhibits MCL-1-NOXA interactions with an IC 50 of approximately 1 μM, while having no effect on BCL-2-BIM or BCL-XL-BCL-XS interactions. The NSCLC cell lines H2110 and H23 are sensitive to A-1210477 with cell viability IC 50 <10 μM, confirming that A-1210477 can kill MCL-1-dependent cell lines.
A-1210477 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-07-06 | 46790 | A-1210477, 95% | 1668553-26-1 | 100mg | 4487 |
| 2026-06-05 | HY-12468 | 1668553-26-1 | 1 mg | 266 |
