Eicosapentaenoic acid ethyl ester-d5

Eicosapentaenoic acid ethyl ester-d5 is intended for use as an internal standard for the quantification of eicosapentaenoic acid ethyl ester (Item No. 10008884) by GC- or LC-MS. Eicosapentaenoic acid (EPA) ethyl ester is an esterified form of the ω-3 fatty acid EPA (Item Nos. 90110 | 90110.1 | 21908). Dietary administration of EPA ethyl ester (41.4 g/100 g of total dietary fatty acids) increases the ex vivo activity of hepatic β-oxidation enzymes.1,2 It also reduces total hepatic triglyceride levels and increases the ω-3 fatty acid content of hepatic triglycerides and phospholipids, as well as increases the total levels of ω-3 fatty acids in rats. EPA ethyl ester (1 g/kg) reverses increases in plasma cholesterol levels and reduces circulating triglyceride levels in rats fed a high-fat diet.3 Formulations containing eicosapentaenoic acid ethyl ester have been used as adjuncts in the treatment of hypertriglyceridemia.WARNING This product is not for human or veterinary use.

[1] DANG DIEM HONG. Divergent effects of eicosapentaenoic and docosahexaenoic acid ethyl esters, and fish oil on hepatic fatty acid oxidation in the rat[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2003, 1635 1: Pages 29-36. DOI: 10.1016/j.bbalip.2003.10.003
[2] PREMAKUMARA G. ARACHCHIGE  Takashi I  Yoko Takahashi. Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats[J]. Metabolism: clinical and experimental, 2006, 55 3: Pages 381-390. DOI: 10.1016/j.metabol.2005.09.013
[3] NEREA PÉREZ-ECHARRI. Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats[J]. Journal of Nutritional Biochemistry, 2009, 20 9: Pages 705-714. DOI: 10.1016/j.jnutbio.2008.06.013