Eicosapentaenoic acid-d
5 ethyl ester is intended for use as an internal standard for the quantification of eicosapentaenoic acid ethyl ester by GC- or LC-MS. Eicosapentaenoic acid (EPA) ethyl ester is an esterified form of the ω-3 fatty acid EPA . Dietary administration of EPA ethyl ester (41.4 g/100 g of total dietary fatty acids) increases the
ex vivo activity of hepatic β-oxidation enzymes.
1,2 It also reduces total hepatic triglyceride levels and increases the ω-3 fatty acid content of hepatic triglycerides and phospholipids, as well as increases the total levels of ω-3 fatty acids in rats. EPA ethyl ester (1 g/kg) reverses increases in plasma cholesterol levels and reduces circulating triglyceride levels in rats fed a high-fat diet.
3 Formulations containing eicosapentaenoic acid ethyl ester have been used as adjuncts in the treatment of hypertriglyceridemia.
1. Hong, D.D., Takahashi, Y., Kushiro, M., et al. Divergent effects of eicosapentaenoic and docosahexaenoic acid ethyl esters, and fish oil on hepatic fatty acid oxidation in the rat Biochim. Biophys. Acta 1635(1),29-36(2003).
2. Arachchige, P.G., Takahashi, Y., and Ide, T. Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats Metabolism 55(3),381-390(2006).
3. Pérez-Echarri, N., Pérez-Matute, P., Marcos-Gómez, B., et al. Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats J. Nutr. Biochem. 20(9),705-714(2008).
