Ampicillin-d
5 is intended for use as an internal standard for the quantification of ampicillin by GC- or LC-MS. Ampicillin is a broad-spectrum antibiotic with activity against Gram-positive and Gram-negative bacteria, including veterinary isolates of
S. pseudintermedius,
S. aureus,
E. coli,
Pasteurella, and
S. canis (MIC
50s = 0.25, 0.5, 2, 0.12, and 0.25 μg/ml, respectively).
1 In vivo, ampicillin (80 mg/kg, i.v.) reduces cough frequency, tachypnea, dyspnea, and fever and increases survival in a baboon (
P. cynocephalus) model of pneumococcal pneumonia.
2 Formulations containing ampicillin have been used to treat a variety of bacterial infections.
