Description
Ampicillin-d
5 is intended for use as an internal standard for the quantification of ampicillin by GC- or LC-MS. Ampicillin is a broad-spectrum antibiotic with activity against Gram-positive and Gram-negative bacteria, including veterinary isolates of
S. pseudintermedius,
S. aureus,
E. coli,
Pasteurella, and
S. canis (MIC
50s = 0.25, 0.5, 2, 0.12, and 0.25 μg/ml, respectively).
1 In vivo, ampicillin (80 mg/kg, i.v.) reduces cough frequency, tachypnea, dyspnea, and fever and increases survival in a baboon (
P. cynocephalus) model of pneumococcal pneumonia.
2 Formulations containing ampicillin have been used to treat a variety of bacterial infections.
Uses
Labelled Ampicillin. Orally active, semi-synthetic antibiotic
References
1. Awji, E.G., Damte, D., Lee, S.-J., et al.
The in vitro activity of 15 antimicrobial agents against bacterial isolates from dogs J. Vet. Med. Sci. 74(8),1091-1094(2012).
2. Reyes, L.F., Restrepo, M.I., Hinojosa, C.A., et al.
A non-human primate model of severe pneumococcal pneumonia PLoS One 11(11),e0166092(2016).
