In anesthetized rats, Dehydro Palonosetron (RS 42358-197), administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 μg/kg; i.v., 5.7 μg/kg; i.d., and 11.6 μg/chamber, respectively)[1].
Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral administration; once) disinhibits behaviour in the mouse suppressed by the aversive situation of the light/dark test box[2].
| Animal Model: | Male albino BKW mice (30-35 g)[2] |
| Dosage: | 0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg |
| Administration: |
Oral administration; once |
| Result: | Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber. |
