Methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate

56441-97-5

61032-41-5

4.1.4 Synthesis of methyl 4-benzyloxy-5-methoxy-2-nitrobenzoate (12): intermediate 11 (10.1 g, 37 mmol) was suspended in acetic acid (100 mL) and 70% nitric acid (20 mL) was added slowly. Subsequently, the reaction mixture was heated to 50 °C and maintained at this temperature for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and poured into ice water (500 mL). After stirring for 1 hour, the precipitate precipitated was collected by filtration, washed with water and dried to give nitro compound 12 as a white solid. Yield: 86%, melting point: 126-128°C.