基本属性 生物活性靶点体外研究体内研究 用途与合成方法 2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸 价格(试剂级) 上下游产品信息 供应商 供应信息 相关产品
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2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸

2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸

英文名称:Bardoxolone
CAS号:218600-44-3
分子式:C31H41NO4
分子量:491.66
EINECS号:
Mol文件:218600-44-3.mol
2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸 结构式

2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸 性质

熔点 180-182 °C
沸点 632.9±55.0 °C(Predicted)
密度 1.18
储存条件 Sealed in dry,Store in freezer, under -20°C
溶解度 DMSO 中≥49.2 mg/mL;不溶于水;温和加热和超声波下,乙醇中≥2.682 mg/mL
形态 固体
酸度系数(pKa) 4.52±0.70(Predicted)
颜色 白色至黄色

2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸 用途与合成方法

Bardoxolone (CDDO, RTA 401)通过从KEAP1释放Nrf2起作用,是Nrf2的激活剂,可以诱导癌细胞凋亡。
TargetValue
Nrf2
()

Bardoxolone methyl, a novel synthetic triterpenoid and antioxidant inflammation modulator, potently induces Nrf2 and inhibits NF-κB and Janus-activated kinase/STAT signaling. Bardoxolone methyl has been shown to induce differentiation, inhibit proliferation, and induce apoptosis in cancer cell lines.

Kidney sections from Bardoxolone methyl-treated monkeys demonstrates decreased megalin protein expression despite similar mRNA expression across groups. The visualized decrease in megalin protein expression is confirmed by densitometry analyses, which demonstrated that Bardoxolone methyl administration significantly decreased megalin protein expression in the monkey kidney. Bardoxolone methyl administration does not affect the protein expression of cubilin in the kidney or the mRNA expression of cubilin in the kidney. The creatinine clearance in monkeys administered Bardoxolone methyl significantly differed from that at baseline and in vehicle-treated animals on day 28. After 28 days of Bardoxolone methyl administration, urinary albumin-to-creatinine ratios (UACRs), determined from the 24-hour urine collections, are significantly increased compared with those in animals receiving vehicle. Of note, UACRs decreases 53.3% in vehicle-treated animals and increased 27.9% in Bardoxolone methyl-treated monkeys. Male C57BL/6J mice are administered oral BARD during HFD feeding (HFD/BARD), only fed a high-fat diet (HFD), or fed low-fat diet (LFD) for 21 weeks. Compared with LFD mice, HFD mice have a marked increase in the number of F4/80 crown-like structures (+95%; p<0.001), which is effectively prevented by BARD (−50%; p<0.01). Similarly, the number of F4/80 interstitial macrophages is significantly higher in HFD mice by 98% (p<0.001) compared with LFD mice and by 32% (p<0.01) compared with HFD/BARD mice.

2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 S6647 2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸 218600-44-3 5mg 970.53
2024-11-08 S6647 2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸 218600-44-3 25mg 2970.62

2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸 上下游产品信息

2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸供应商 更多

上海玛维生物科技有限公司
联系电话: 13671830408
产品介绍:
中文名称:巴多索隆
英文名称:Bardoxolone
CAS:218600-44-3
纯度:98%+
包装信息:1g/RMB 3000
备注:1mg,5mg,10mg,100mg,5g,10g,100g
上海喀露蓝科技有限公司
黄金产品 现货
联系电话:18149758185 18149758185
产品介绍:
中文名称:2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸
英文名称:Bardoxolone
CAS:218600-44-3
纯度:98%
包装信息:10mg;100mg;1g;10g;100g;1kg
备注:1g
库存量:1g
现货日期:2024/12/19 9:09:46
上海精津化工科技有限公司
黄金产品
联系电话:021-13817626287 13817626287
产品介绍:
中文名称:2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸
英文名称:2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid
CAS:218600-44-3
纯度:98% HNMR HPLC
包装信息:5g;10g;100g
安庆研至医药科技有限公司
大货 现货
联系电话: 18055651951
产品介绍:
英文名称:Bardoxolone
CAS:218600-44-3
纯度:98%+
包装信息:5mg; 10mg; 1g; 10g;100g; 1kg; 5Kg; 10Kg
库存量:20g
现货日期:2024/12/17 14:48:01
北京百灵威科技有限公司
联系电话:010-82848833 400-666-7788
产品介绍:
中文名称:2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸, 一种新型核调节因子 (Nrf-2)激活剂
英文名称:Bardoxolone, 98%, a novel nuclear regulator factor (Nrf-2) activator
CAS:218600-44-3
纯度:98%
包装信息:10MG
备注:化学试剂、精细化学品、医药中间体、材料中间体

最新发布供应信息

218600-44-3Bardoxolone
上海嘉定区澄浏公路52号 2024-12-19
齐墩果烷三萜化合物|T2915
上海陶术生物科技有限公司 2024-12-02

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