alpha-Guanidinoglutaric acid

Product Namealpha-Guanidinoglutaric acid
CAS73477-53-9
MFC6H11N3O4
MW189.17
EINECS
MOL File73477-53-9.mol

Chemical Properties

Boiling point	414.7±55.0 °C(Predicted)
Density	1.62±0.1 g/cm3(Predicted)
refractive index	-20 ° (C=4, 2mol/L HCl)
storage temp.	2-8°C
solubility	PBS pH 7.2: >50 mg/ml
form	White crystalline solid.
pka	3.28±0.10(Predicted)
color	White to Almost white

Safety Information

HS Code

2925.29.6000

Usage And Synthesis

Description

GGA is a linear mixed-type inhibitor of nNOS having a K_i of 2.69 μM. It is normally present in small quantities in the cerebral cortex of cats with increased levels following seizure.

Uses

α-Guanidinoglutaric acid is a guanidino compound first found in cobaltinduced epileptogenic focus tissue in the cerebral cortex of cats. α-Guanidinoglutaric acid induces epileptic seizures in rats after intraventricular administration[1].

Definition

ChEBI: N-Amidino-L-glutamate is a L-glutamic acid derivative.

References

[1] H Shiraga, et al. Convulsive activity of alpha-guanidinoglutaric acid and the possible involvement of 5-hydroxytryptamine in the alpha-guanidinoglutaric acid-induced seizure mechanism. J Neurochem. 1986 Dec;47(6):1832-6. DOI:10.1111/j.1471-4159.1986.tb13095.x