General procedure: pre-step A Synthesis of 5-fluoro-4-pyrimidinamine
A mixture of 4-chloro-5-fluoropyrimidine (200 mg, 1.509 mmol) and ammonia (3.3 mL, 45.3 mmol) in methanol (580 μL) was placed in a microwave reactor, heated to 110 °C, and reacted for 30 min. Upon completion of the reaction, the reaction mixture was filtered and the solid product was collected and dried to give 5-fluoropyrimidin-4-amine (100 mg, 0.875 mmol, 58% yield) as a white solid. Mass spectrum (electrospray positive ion mode) m/z 114.1 ([M+H]+).
