Basic information Safety Related Supplier

3'-ADENYLIC ACID

Basic information Safety Related Supplier
3'-ADENYLIC ACID Basic information
3'-ADENYLIC ACID Chemical Properties
  • Melting point:~210 °C (dec.)
  • storage temp. -20°C
  • pkapK1: 3.65(0);pK2: 5.88(-1) (25°C)
  • Water Solubility 0.5g/L(15 ºC)
  • Merck 13,158
  • BRN 54478
  • EPA Substance Registry System3'-Adenylic acid (84-21-9)
Safety Information
  • Safety Statements 22-24/25
  • WGK Germany 3
  • RTECS AU7480320
  • 10-21
MSDS
3'-ADENYLIC ACID Usage And Synthesis
  • Uses
    Adenosine 3′-monophosphate (3′-AMP) is a metabolite produced from hydrolysis of 2′,3′-cAMP by a family of metal-dependent phosphodiesterases. 3′-AMP inhibits proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. 2′,3′-cAMP and 3′-AMP represent a new unexplored pathway for adenosine-based cell regulation.
  • Purification MethodsIt crystallises from large volumes of H2O in needles as the monohydrate, but is not very soluble in boiling H2O. Under acidic conditions it forms an equilibrium mixture of 2' and 3' adenylic acids via the 2',3'-cyclic phosphate. When heated with 20% HCl, it gives a quantitative yield of furfural after 3hours, unlike 5'-adenylic acid which only gives traces of furfural. The yellow monoacridine salt has m 175o(dec), and the diacridine salt has m 177o (225o)(dec). [Brown & Todd J Chem Soc 44 1952, Takaku et al. Chem Pharm Bull Jpn 21 1844 1973, NMR: Ts'O et al. Biochemistry 8 997 1969, Beilstein 26 III/IV 3607.]
3'-ADENYLIC ACID(84-21-9)Related Product Information
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