Bax Inhibitor Peptide V5 (trifluoroacetate salt)

Bax inhibitor peptide V5 is an inhibitor of Bax.1 It decreases levels of the pro-apoptotic proteins Bax, Bad, and NF-ĸB p65 and increases levels of the anti-apoptotic proteins X-linked inhibitor of apoptosis (XIAP) and Bcl-2 in isolated mouse pancreatic islets when used at a concentration of 100 µM.2 It inhibits apoptosis induced by etoposide (Item No. 12092) in Hep3B human hepatoma cells when used at a concentration of 200 µM.1 Bax inhibitor peptide V5 (5 mg/ml, i.c.v.) decreases infarct volume and reduces ipsilateral paw preference in the cylinder rearing test, indicating an improvement in sensorimotor function, in a neonatal mouse model of hypoxic-ischemia brain injury induced by carotid artery ligation.3 Bax inhibitor peptide V5, when used at a concentration of 100 µM in syngeneic pancreatic islet cells prior to transplantation, inhibits increases in blood glucose levels in an intraperitoneal glucose tolerance test and increases survival in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).2WARNING This product is not for human or veterinary use.

[1] TOMOYUKI YOSHIDA . Bax-inhibiting peptide derived from mouse and rat Ku70[J]. Biochemical and biophysical research communications, 2004, 321 4: Pages 961-966. DOI: 10.1016/j.bbrc.2004.07.054
[2] JORGE D RIVAS-CARRILLO. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice.[J]. Diabetes, 2007, 56 5: 1259-1267. DOI: 10.2337/db06-1679
[3] XIAOYANG WANG. Neuroprotective effect of Bax-inhibiting peptide on neonatal brain injury.[J]. Stroke, 2010, 41 9: 2050-2055. DOI: 10.1161/strokeaha.110.589051