RGD Peptide (trifluoroacetate salt)

RGD peptide is a synthetic compound made up of the arginine-glycine-aspartate motif that has been extensively used to inhibit integrin-ligand interactions in studies related to cell adhesion, migration, growth, and differentiation.1 RGD peptide has also been shown to directly induce apoptosis, independent of integrin-mediated cell clustering or signals, by initiating conformational changes that enhance pro-caspase-3 activation and autoprocessing.2,3WARNING This product is not for human or veterinary use.

[1] ERKKI RUOSLAHTI  Björn Ö. Common Principles in Cell Adhesion[J]. Experimental cell research, 1996, 227 1: Pages 1-11. DOI: 10.1006/excr.1996.0243
[2] CHRISTOPHER D. BUCKLEY. RGD peptides induce apoptosis by direct caspase-3 activation[J]. Nature, 1999, 397 6719: 534-539. DOI: 10.1038/17409
[3] S R ADDERLEY  D J F. Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activation.[J]. The Journal of Biological Chemistry, 2000, 275 8: 5760-5766. DOI: 10.1074/jbc.275.8.5760