2-Bromo-4,6-diphenyl-[1,3,5]triazine

14921-00-7

98-80-6

80984-79-8

Under nitrogen protection, 2,4,6-tribromo-1,3,5-triazine ring (31.78 g, 100.05 mmol) and phenylboronic acid (12.19 g, 100.01 mmol) were added to a 2L reactor, followed by potassium carbonate (1.24 g, 9.00 mmol) and 200 mL of toluene as solvent. After heating the reaction mixture to 70 °C, tetrakis(triphenylphosphine)palladium (1.04 g, 0.90 mmol) was added as a catalyst. Next, 100 mL of distilled water was added and the reaction mixture was stirred and refluxed for 11 hours to ensure complete reaction. Upon completion of the reaction, 70 mL of distilled water was added to quench the reaction. The mixture was separated by filtration under reduced pressure and the solid product was washed with distilled water. Subsequently, recrystallization was carried out using toluene followed by THF solidification and finally further purification by sublimation and recrystallization from toluene afforded the intermediate 2-bromo-4,6-diphenyl-1,3,5-triazine (30.89 g in 84.10% yield).