A component of our recommended catalyst for conjugating azides with alkynes using a copper-catalyzed click reaction. This inactive complex is stable and contains divalent copper(II) as 10 mM CuSO4 in 55% aqueous DMSO.
When Cu(II)-TBTA is treated with reducing agents, such as ascorbic acid, a catalytically active complex with monovalent copper (I) is formed.
