A bisbenzylisoquinoline alkaloid, this base has been isolated from Cocculus
sarmentosus Diels and C. trilobus DC. It crystallizes as colourless prisms and is
dextrorotatory with [α]29D + 296.3° (CHCI3). Both the hydrochloride and hydro_x0002_bromide are crystalline and sparingly soluble in H20 and the dimethiodide has
m.p. 273°C (dec.). Two methoxyl groups and two methylimino groups are
present. With dimethyl sulphate in NaOH, the base yields trilobinemethylmethine
as long, colourless prisms, m.p. 106° C which is optically inactive and on ozonization furnishes 2-methoxy-5:4'-dialdehydodiphenyl ether, m.p. 72-5°C and a
complex dialdehyde, m.p. 124°C.
Kondo, Tomita., J. Pharm. Soc., Japan, 47, 39 (1927)
Kondo, Tomita., ibid, 48, 83 (1928)
Kondo, Tomita., ibid, SO, 91 (1930)
Faltis., Annalen, 497,69 (1932)
Kondo, Tomita., Arch. Pharm., 274, 65 (1936)
Faltis et al., Ber., 74,79 (1941)
