Description
A bisbenzylisoquinoline alkaloid, this base has been isolated from Cocculus
sarmentosus Diels and C. trilobus DC. It crystallizes as colourless prisms and is
dextrorotatory with [α]
29D + 296.3° (CHCI3). Both the hydrochloride and hydro_x0002_bromide are crystalline and sparingly soluble in H20 and the dimethiodide has
m.p. 273°C (dec.). Two methoxyl groups and two methylimino groups are
present. With dimethyl sulphate in NaOH, the base yields trilobinemethylmethine
as long, colourless prisms, m.p. 106° C which is optically inactive and on ozonization furnishes 2-methoxy-5:4'-dialdehydodiphenyl ether, m.p. 72-5°C and a
complex dialdehyde, m.p. 124°C.
References
Kondo, Tomita., J. Pharm. Soc., Japan, 47, 39 (1927)
Kondo, Tomita., ibid, 48, 83 (1928)
Kondo, Tomita., ibid, SO, 91 (1930)
Faltis., Annalen, 497,69 (1932)
Kondo, Tomita., Arch. Pharm., 274, 65 (1936)
Faltis et al., Ber., 74,79 (1941)
