Benzamide, 3-[4-(aminocarbonyl)phenoxy]-

PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC50s of 1.7 μM for human PARP2 and human PARP15, respectively[1].

human PARP10: 480 nM (IC₅₀); human PARP2: 1.7 μM (IC₅₀); human PARP15: 1.7 μM (IC₅₀); human TNKS2: 6.5 μM (IC₅₀); human PARP4: 7 μM (IC₅₀); human TNKS1: 21 μM (IC₅₀); human PARP14: 41 μM (IC₅₀); human PARP12: >10 μM (IC₅₀); human PARP16: >10 μM (IC₅₀); human PARP1: >100 μM (IC₅₀); human PARP3: >100 μM (IC₅₀)

[1] Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948. DOI:10.1002/open.202100087