RUBROPUNCTATIN

Chemical Properties

Melting point	156.5-157.0 °C (decomp)(Solv: ethyl ether (60-29-7))
Boiling point	638.8±55.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
form	Solid
color	Yellow to orange
InChI	InChI=1S/C21H22O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10-12H,4,6-7,9H2,1-3H3/b8-5+/t21-/m1/s1
InChIKey	SULYDLFVUNXAMP-WKOQKXSESA-N
SMILES	C1(/C=C/C)OC=C2C(=O)[C@]3(C)OC(=O)C(C(=O)CCCCC)=C3C=C2C=1

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Animal Model:	Male nude mice (5 weeks) are inoculated with BGC-823 cells^[1]
Dosage:	8, 32 mg/kg
Administration:	I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result:	Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg). Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg). No significant difference was observed on the body weight.