Seclazone, a heterocyclic compound, possesses anti-inflammatory, analgesic, antipyretic and diuretic properties. Seclazone is orally active[1].
in vivo
Seclazone (220 mg/kg; p.o.; dietary, daily) inhibits the development of adjuvant-induced polyarthritis in rats[1].
Seclazone significantly lowers the fever induced in rats by administration of a yeast suspension[1].
Animal Model:
Male Charles River rats (150-170 g) [1]
Dosage:
220 mg/kg
Administration:
Oral administration, dietary, daily
Result:
Inhibited adjuvant-induced polyarthritis
References
[1] F M Berger, et al. The pharmacological properties of seclazone (7-chloro-3,3a-dihydro-2H, 9H-isoxazolo (3,2-b) (1,3) benzoxazin-9-one) a new anti-inflammatory agent. Pharmacology. 1973;9(3):164-76. DOI:10.1159/000136381
