NU6140
NU6140 性质
| 沸点 | 707.8±70.0 °C(Predicted) |
|---|---|
| 密度 | 1.234±0.06 g/cm3(Predicted) |
| 储存条件 | Desiccate at +4°C |
| 溶解度 | DMF：30mg/mL； DMSO：30mg/mL；乙醇：30mg/mL；乙醇:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| 形态 | 白色至类白色固体。 |
| 酸度系数(pKa) | 9.41±0.10(Predicted) |
| 颜色 | 白色至浅黄色 |
NU6140 用途与合成方法
|
cdk2-cyclin A 0.41 μM (IC 50 ) |
CDK1-Cyclin B 6.6 μM (IC 50 ) |
CDK4-Cyclin D 5.5 μM (IC 50 ) |
cdk5-p25 15 μM (IC 50 ) |
cdk7-cyclin H 3.9 μM (IC 50 ) |
Aurora A 67 nM (IC 50 ) |
Aurora B 35 nM (IC 50 ) |
NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H, with IC
50
s of 6.6, 5.5, 15 and 3.9 μM, respectively.
NU6140 increases catalytic activity of capase-9 and capase-3, causes increase in the sub-G1 apoptotic cell population.
NU6140 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-107419 | NU6140 | 444723-13-1 | 5mg | 1200 |
| 2024-11-08 | HY-107419 | NU6140 | 444723-13-1 | 10mM * 1mLin DMSO | 1320 |
