PantoprazoleSodiumSesquihydrate

Chemical Properties

storage temp.	4°C, protect from light
solubility	Freely soluble in water and in ethanol (96 per cent), practically insoluble in hexane.
form	Solid
color	White to off-white
Major Application	pharmaceutical (small molecule)
InChI	1S/C16H16F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15-16,21H,8H2,1-2H3;;1H2/q-1;+1;
InChIKey	QHNXIKDJFYGZTL-UHFFFAOYSA-N
SMILES	[Na+].FC(F)Oc1cc2c(cc1)[N-]C(N2)[S](=O)Cc3nccc(c3OC)OC.O

Animal Model:	Mice bearing MCF-7 or A431 xenografts^[1]
Dosage:	200 mg/kg
Administration:	IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)
Result:	Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination. Significantly increased tumor growth delay with a single dose with Doxorubicin. There is no effect on growth delay alone.