O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine

3,3''-Diiodo-L-thyronine is a metabolite of thyroid hormone that is also known as T2 or 3,3’-T2. It is derived enzymatically from triiodothyronine isoforms T3 and reverse T3. T2 and its analog 3,5-T2 stimulate the activity of cytochrome c oxidase by blocking inhibition by ATP.

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Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

ChEBI: 3,3'-diiodo-L-thyronine is a 3,3'-diiodothyronine. It has a role as a human metabolite.

Human Endogenous Metabolite; COX

[1] G PINNA. 3,3’-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress.[J]. Journal of Clinical Endocrinology & Metabolism, 1998, 83 9: 3071-3077. DOI: 10.1210/jcem.83.9.5080
[2] F. GOGLIA . Interaction of diiodothyronines with isolated cytochromec oxidase[J]. FEBS Letters, 1994, 346 2: Pages 295-298. DOI: 10.1016/0014-5793(94)00476-5
[3] S ARNOLD  B K  F Goglia. 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.[J]. European journal of biochemistry, 1998, 252 2: 325-330. DOI: 10.1046/j.1432-1327.1998.2520325.x