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3-(acetylamino)propanesulphonic acid

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3-(acetylamino)propanesulphonic acid Basic information
Safety Information
3-(acetylamino)propanesulphonic acid Usage And Synthesis
  • OriginatorCampral,Merck
  • UsesTreatment of alcohol dependency.
  • DefinitionChEBI: An organosulfonic acid that is propane-1-sulfonic acid substituted by an acetylamino group at position 3.
  • Manufacturing ProcessIn a 4 liter flask provided with stirring means, a bromine funnel and a thermometer, 17.5% sodium hydroxide solution and aminopropanesulfonic acid (homotaurine) are added.
    After complete dissolution, at a temperature of between 25°-40°C, acetic anhydride are added so as not to exceed a temperature of between 30°-40°C. The mixture is then maintained at this temperature by heating for at least 1 h.
    The solution is then concentrated in vacuum, the residue is redissolved in 2.5 L of distilled water and the mixture is concentrated again. The residue is then dissolved in 1.6 L of distilled water, filtered, then concentrated almost completely. Drying is terminated in an oven in vacuum. A colorless crystalline powder of 3-acetylaminopropanesulfonate of sodium (sodium Nacetylhomotaurinate) is obtained.
    The 3-acetylaminopropanesulfonic acid may be produced by treatment of 3- acetylaminopropanesulfonate of sodium with hydrochloric acid.
    In practice it is usually used as calcium salt.
  • brand nameCampral (Forest).
  • Therapeutic FunctionPsychotropic
3-(acetylamino)propanesulphonic acid (77337-76-9)Related Product Information
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