1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]piperidinium chloride

Piperoxan is an α₂-adrenergic receptor (α₂-AR) antagonist (K_is = 5.4, 2, and 1.3 nM for α_2A-, α_2B-, and α_2C-ARs, respectively) and a first generation histamine receptor antagonist. It reverses decreases in systolic blood pressure induced by clonidine in spontaneously hypertensive rats when administered at a dose of 10 mg/kg.

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO, and HCl.