NBD-Pen

NBD-Pen high-sensitivity, specific fluorescence probe for lipid radicals. NBD-Pen directly detected lipid radicals in living cells by turn-on fluorescence. In a rat model of hepatic carcinoma induced by diethylnitrosamine (DEN), NBD-Pen detected lipid radical generation within 1 hour of DEN administration.

NBD-Pen is a fluorescence probe. NBD-Pen can be used for the research of detection of lipid-derived radicals[1].

[1] Ishida Y, et al. Detection and inhibition of lipid-derived radicals in low-density lipoprotein. Free Radic Biol Med. 2017 Dec;113:487-493. DOI:10.1016/j.freeradbiomed.2017.10.388
[2] KEN-ICHI YAMADA. Fluorescence probes to detect lipid-derived radicals[J]. Nature chemical biology, 2016, 12 8: 608-613. DOI: 10.1038/nchembio.2105