SEC
中文名称:SEC
英文名称:1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
CAS号:1802997-81-4
分子式:C22H23ClN2O5
分子量:430.88
EINECS号:
Mol文件:1802997-81-4.mol
SEC 性质
| 沸点 | 627.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 13.31±0.20(Predicted) |
| 形态 | 油状物 |
| 颜色 | 浅黄至黄色 |
SEC 用途与合成方法
SEC 通过 AMPK/mTORC1/STAT3 信号通路诱导 ANXA7 GTPase 的激活。SEC 选择性的促进癌细胞的凋亡，诱导 ITGB4 核转位，表达高水平 ITGB4。
SEC (20 µM) inhibits the cell migration of HEK 293T RKIP
−/−
cells and PC3 prostate cancer cells.
SEC (20 µM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (
cell selectively
).
Cell Viability Assay
| Cell Line: | HEK293T RKIP −/− cells. [1] |
| Concentration: | 20 µM. |
| Incubation Time: | 24 h. |
| Result: | Suppressed HEK293T RKIP −/− cell migration while had no effect on HEK293T RKIP +/+ cells. |
SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model.
| Animal Model: |
Luciferase-labeled PC-3M-Luc cells (2×10
6
per 50 µL sterile HBSS
−/−
) are orthotopically inoculated into the prostates of 8-week-old nude mice.
|
| Dosage: | 3 mg/kg/day or 18 mg/kg/day. |
| Administration: | IP daily for 3 weeks. |
| Result: |
Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.
Decreased the mRNA level of CCL2 , APLN and IL6ST in implanted tumors. Did not affect the body weight of the mice. |
SEC 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-125355 | 1 mg | 1363 | ||
| 2024-11-08 | HY-125355 | 1802997-81-4 | 5mg | 3000 |
SEC供应商 更多
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：SEC
CAS：1802997-81-4
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
上海雅吉生物科技有限公司
联系电话：021-34661275 15301693058
产品介绍：
中文名称：金黄色葡萄球菌肠毒素C(SEC)ELISA试剂盒
英文名称：SEC
纯度：99
备注：YS10424B 1盒/RMB 1200
