ChemicalBook Product Catalog API Anesthetic Agents General anesthetics Phenol, 2-[(1R)-1-cyclopropylethyl]-6-(1-methylethyl)-

Phenol, 2-[(1R)-1-cyclopropylethyl]-6-(1-methylethyl)-

Product NamePhenol, 2-[(1R)-1-cyclopropylethyl]-6-(1-methylethyl)-
CAS1637741-58-2
MFC14H20O
MW204.31
EINECS
MOL File1637741-58-2.mol

Chemical Properties

solubility	DMSO: Soluble: =10 mg/ml Ethanol: Soluble: =10 mg/ml
form	Liquid
color	Colorless to light yellow

Usage And Synthesis

Uses

Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABAA receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis[1][2].

in vivo

Cipepofol (Ciprofol; 100 μL; implanted into the abdomen of mice 1 h before ISO) suppresses ISO-induced myocardial damage, cardiac dysfunction, and inflammation and cardiomyocyte apoptosis^[2].

Animal Model:	Eighty male C57BL/6 mice (20-24 g, 8-10 weeks)^[2]
Dosage:	100 μl
Administration:	Implanted into the abdomen of mice 1 h before ISO
Result:	Attenuated increased the content of serum CK-MB, LDH, and cTnT by ISO insults (100 mg/kg; sc; for 2 consecutive days to induce experimental myocardial infarction). Significantly improved ISO-induced LV systolic and diastolic dysfunction. Largely suppressed the increases in IL-6 IL-17 and TNF-α expression.

References

[1] Ming Lu, et al. Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia Biomed Res Int. 2023 Jan 19:2023:7443226. DOI:10.1155/2023/7443226
[2] Yunzhao Yang, et al. Ciprofol attenuates the isoproterenol-induced oxidative damage, inflammatory response and cardiomyocyte apoptosis. Front Pharmacol. 2022 Nov 22:13:1037151. DOI:10.3389/fphar.2022.1037151
[3] LINLIN QIN*. Design, Synthesis, and Evaluation of Novel 2,6-Disubstituted Phenol Derivatives as General Anesthetics[J]. Journal of Medicinal Chemistry, 2017, 60 9: 3606-3617. DOI: 10.1021/acs.jmedchem.7b00254

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