抗人CD28抗体

Anti-CD28 Antibody, Rabbit Polyclonal.

ELISA

Reacts with: Human

Reacts with: Human

Recombinant Human CD28 protein (Catalog#11524-H08H)

Produced in rabbits immunized with purified, recombinant Human CD28 (rh CD28; Catalog#11524-H08H; P10747-1; Met 1-Pro 152). CD28 specific IgG was purified by Human CD28 affinity chromatography.

CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

抗人CD28抗体是一类以CD28为抗原的多克隆抗体，可以特异性结合CD28，主要用于检测CD28的Western Blot、IHC-P、IF、ELISA、Co-IP等多种免疫学实验。