4-Propylresorcinol

5792-36-9

18979-60-7

The general procedure for the synthesis of 4-propylresorcinol from 2',4'-dihydroxypropiophenone is as follows: 100 g of 4-propionylresorcinol was dissolved in 100 mL of methanol. To the solution, 30g of nickel catalyst was added and the mixture was placed in a suitable autoclave for hydration reaction at 60-80°C and 10-20 bar. The gas chromatographic (GC) purity of the feedstock needs to be >92%. Upon completion of the reaction, the catalyst was removed by filtration and most of the methanol was removed by distillation. Subsequently, 400 mL of toluene was added and the mixture continued to be distilled until the top temperature indicated that the methanol had been completely removed. The mixture was cooled to room temperature and the product was collected by filtration. After washing the product with toluene and drying, 4-propylresorcinol was obtained in 81% yield and ≥99% purity.