腺苷5'-二磷酸核糖钠
腺苷5'-二磷酸核糖钠 性质
| 储存条件 | -20°C |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色至浅黄色 |
| 水溶解性 | Water : 125 mg/mL (215.04 mM) |
| InChIKey | MBPRZUBFEMLFGQ-UUIVKEFHSA-M |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.[NaH] |&1:1,2,3,15,17,19,24,r| |
腺苷5'-二磷酸核糖钠 用途与合成方法
TRPM2 channel
Autophagy
In mouse embryonic fibroblasts (MEFs), H
2
O
2
treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca
2+
elevation through extracellular Ca
2+
influx and (or) lysosomal Ca
2+
release. This process eventually activates early or late autophagy in response to different degrees of oxidative stress.
TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus. In addition to ADPR, intracellular Ca
2+
is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.
腺苷5'-二磷酸核糖钠 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-08-19 | HY-100973A | 5 mg | 750 | ||
| 2024-08-19 | HY-100973A | 腺苷5'-二磷酸核糖钠 | 68414-18-6 | 10mg | 1200 |
