1-Methyl-1H-indole-6-carboxylic acid 97

1204-32-6

202745-73-1

Step 2: Synthesis of 1-methyl-1H-indole-6-carboxylic acid (167). Methyl 1-methyl-1H-indole-6-carboxylate (166, 1.24 mmol) was reacted with sodium hydroxide (0.59 g, 14.88 mmol) in a solvent mixture of methanol/THF/water (2:2:1, 7.5 mL) with stirring for 36 h at room temperature. A precipitate was generated during the reaction and the precipitate was collected by filtration followed by lyophilization overnight to afford the target product 1-methyl-6-indolecarboxylic acid (167, 0.54 g, 99% yield). Mass spectral data: calculated (Calc) 175.06, observed (Obs) 176.1.