CYTIDINE 5'-MONOPHOSPHO-N-

Product NameCYTIDINE 5'-MONOPHOSPHO-N-
CAS3063-71-6
MFC20H31N4O16P
MW614.45
EINECS
MOL File3063-71-6.mol

Chemical Properties

Density	2.02±0.1 g/cm3(Predicted)
storage temp.	-20°C
form	solid
pka	1.30±0.50(Predicted)
color	white
Water Solubility	water: 20mg/mL
BRN	4224251
InChIKey	VFRHSOGUONIUOR-SQQGBWPWNA-M
SMILES	[P](=O)(OC3(OC(C(C(C3)O)NC(=O)C)C(O)C(O)CO)C(=O)O)(OCC1OC(C(C1O)O)N2C=CC(=NC2=O)N)O

Safety Information

Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3
F	10-21
Storage Class	13 - Non Combustible Solids

Usage And Synthesis

Uses

Cytidine-5′-monophospho-N-acetylneuraminic acid sodium salt has been used:

as a standard in high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD) for nucleotide sugar analysis in Joubert syndrome type 10 (JBTS10) patient cells and control skin fibroblasts,
As a substrate for the enzymatic sialylation of G2 glycoforms, resialylation assay,
in in-vitro sialyltransferase assay

Definition

ChEBI: CMP-N-acetyl-beta-neuraminic acid is a nucleotide sugar used as a donor by glycosyltransferases for the synthesis of sugar chains It has a role as a mouse metabolite. It is functionally related to a N-acetyl-beta-neuraminic acid. It is a conjugate acid of a CMP-N-acetyl-beta-neuraminate(2-).

General Description

Cytosine 5′-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac) is a sugar-nucleotide produced by CMP-Neu5Ac synthetase from CTP and Neu5Ac.

Biochem/physiol Actions

Cytidine-5′-monophospho-N-acetylneuraminic acid (CMP-Sialic acid) is a substrate for sialyltransferases. It is used for the enzymatic sialylation of glycans.

IC 50

Human Endogenous Metabolite