MA-0204

Product NameMA-0204
CAS2095128-17-7
MFC25H27F3N2O4
MW476.49
EINECS
MOL File2095128-17-7.mol

Chemical Properties

Boiling point	611.9±65.0 °C(Predicted)
Density	1.23±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	4.76±0.10(Predicted)
color	White to off-white

Usage And Synthesis

Uses

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1].

in vivo

PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle^[1].

IC 50

PPARδ: 0.4 nM (EC₅₀, in human); PPARδ: 7.9 nM (EC₅₀, in mouse); PPARδ: 10 nM (EC₅₀, in rat)

References

[1] Lagu B, et al. Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD). ACS Med Chem Lett. 2018 Jul 31;9(9):935-940. DOI:10.1021/acsmedchemlett.8b00287